利用乳液聚合法制备分散性良好的聚（N-异丙基丙烯酰胺）（PNIPAM）微凝胶，再以微凝胶为交联点制备PNIPAM水凝胶。分析微凝胶粒径、双键质量摩尔浓度对PNIPAM水凝胶溶胀度的影响，结果表明，水凝胶在25~50℃的溶胀度最大能达到4 054.35%。分别采用原位包裹和后包裹法制备了载药水凝胶，体外释放结果表明，水凝胶的结构和载药方式对释药行为有影响，其中含原位包裹微凝胶的载药水凝胶缓释效果最好。

Poly(N-isopropylacrylamide) (PNIPAM) microgel with good dispersity is fabricated via emulsion polymerization method.PNIPAM composite hydrogel is prepared by using PNIPAM microgel as micro-crosslinkers.The effects of double bond contents and particle size of microgels on the swelling degree of PNIPAM hydrogels are investigated.It is found that the thermo-responsive swelling ratio of the hydrogels is as high as 4 054.35% when the environmental temperature increases from 25℃ to 50℃.Meanwhile,PNIPAM microgels containing urapidil hydrochloride are obtained by in-situ encapsulation method and post-encapsulation method,respectively.The release study indicates that drug-release property is related to the structure of PNIPAM hydrogels and drug supporting mode,and the urapidil hydrochloride-PNIPAM hydrogel by in-site encapsulation microgels exhibits better sustained-release capacity.

孙瑞鸿(1991-),女,硕士生,研究方向为高分子材料,849874106@qq.com